| 摘要 |
Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R1 represents an alkyl group or the like; Y represents a hydrogen atom; X represents a halogen atom or the like; j and k each represent 0 or 1; R2 and R3 each represent an alkyl group or the like; R11 to R19 each represent a hydrogen atom, an alkyl group or the like; Z represents oxygen or sulfur; n1 represents 1 or 2; and n2 represents an integer from 1 to 3, a method for producing the ruthenium complex, a catalyst for asymmetric reduction formed from the ruthenium complex, and methods for selectively producing an optically active alcohol and an optically active amine using the catalyst for asymmetric reduction.; |
| 主权项 |
1. A ruthenium complex represented by the following formula (1): wherein symbol * represents an asymmetric carbon atom; R1 represents an alkyl group having 1 to 10 carbon atoms; a halogenated alkyl group having 1 to 10 carbon atoms; 10-camphoryl group; an amino group which is optionally substituted with one or two alkyl group having 1 to 10 carbon atoms; an aryl group which is optionally substituted with an alkyl group having 1 to 10 carbon atoms, a halogenated alkyl group having 1 to 10 carbon atoms, a halogen atom, a cyano group (—CN), an amino group, an alkylated amino group (—NR20R21), a five or six membered cyclic amino group, an acylated amino group (—NH—CO—R20), a hydroxyl group, an alkoxy group (—OR20), an acyl group (—CO—R20), a carboxyl group, an alkoxycarbonyl group (—COOR20), a phenoxy carbonyl group, a mercapto group, an alkylthio group (—SR20), a silyl group (—SiR20R21R22), or a nitro group (—NO2); R20, R21 and R22 each independently represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms or a cycloalkyl group having 3 to 10 carbon atoms; Y represents a hydrogen atom; X represents a trifluoromethanesulfonyloxy group, a p-toluenesulfonyloxy group, a methanesulfonyloxy group, a benzenesulfonyloxy group, a hydrogen atom, or a halogen atom; j and k each represent 0 or 1, but j+k is not 1; R2 and R3 each independently represent a hydrogen atom; an alkyl group having 1 to 10 carbon atoms; a phenyl group which is optionally substituted with an alkyl group having 1 to 10 carbon atoms, an alkoxy group having 1 to 10 carbon atoms, or a halogen atom; or a cycloalkyl group having 3 to 8 carbon atoms, or R2 and R3 is optionally joined together to form a ring; R11, R12, R13, R14 and R15 each independently represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, or an alkoxy group having 1 to 10 carbon atoms; R16 and R17 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 10 carbon atoms, or an alkoxy group having 1 to 10 carbon atoms, or one R16 and one R17 with the carbon atom which is substituted with said one R16 and one R17 form a carbonyl group; R18 and R19 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 10 carbon atoms, or an alkoxy group having 1 to 10 carbon atoms, or one R18 and one R19 with the carbon atom which is substituted with said one R18 and one R19 form a carbonyl group; Z represents an oxygen atom or a sulfur atom; and n1 represents 1 or 2, and n2 represents 1, 2 or 3. |
