Composite material for tissue repair

摘要

The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.

主权项

1. A method comprising:
identifying a tissue defect in cartilage, a ligament or a tendon for repair; applying a composite in combination with a polymerizable agent to the tissue defect, the composite including a fibrous polymeric component and a hydro gel formed in vitro on the fibrous polymeric component; and reacting the polymerizable agent with tissue at the site of the defect in the absence of a priming agent.