Medicament and method of diagnosis for treating subclinical Cushing's syndrome

摘要

We disclose a diagnostic test to determine suitable therapeutic intervention of subjects suffering from subclinical Cushing's syndrome [SCS] and also agents that antagonize the action of cortisol or inhibit excess cortisol production in the treatment of conditions such as SCS in the presence of an adrenal incidentaloma.

主权项

1. A method to determine a suitable treatment regime for a subject suffering from or having a pre-disposition to subclinical Cushing's syndrome or adrenal incidentaloma, said method comprising:
i) determining the level of cortisol in a sample from the subject and comparing said level to normal cortisol levels as a measure of subclinical Cushing's syndrome in the subject; ii) administering to the subject an effective amount of at least one agent that inhibits the synthesis or activity of cortisol; and iii) analyzing the improvement of hypertension and/or glucose metabolism and/or osteoporosis in said subject as a measure of the response of the subject to the administration of the agent, to determine an improvement or not of the subject's condition and define a suitable treatment regime; iv) detecting an improvement in hypertension and/or glucose metabolism and/or osteoporosis in the subject; and v) treating the subject by surgical intervention.