Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof

摘要

The invention provides an intracardiac occluder, which has biological tissue scaffolds as occlusion shells, for the percutaneous transluminal treatment of an intracardiac defect. The intracardiac occluder includes a proximal support structure supporting the proximal occlusion shell and a distal support structure supporting the distal occlusion shell. In one embodiment, biological tissue derived from the tunica submucosa layer of the porcine small intestine forms the occlusion shells.

主权项

1. An intracardiac occluder clip for permanent implantation in the percutaneous transluminal space to treat an intracardiac defect so as to substantially close the intracardiac defect through host tissue endothelialization, said occluder comprising:
a resilient wire forming opposing proximal and distal support structures for occlusion shells, wherein each support structure is formed of two external stems and two internal stems forming a M-shaped arcuate length of the wire, wherein both external stems of each M-shaped support structure are joined to the external stems of the opposing M-shaped support structure; a proximal occlusion shell providing a scaffold for endothelialization, wherein the shell is formed of a non-porous bioresorbable sheet and is fitted securely between the external and internal stems of the M-shaped proximal support structure; and, a distal occlusion shell providing a scaffold for endothelialization, wherein the shell is formed of a non-porous bioresorbable sheet and is fitted securely between the external and internal stems of the M-shaped distal support structure.