(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-PIPERAZINES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATION

摘要

Inhibitors of LIM kinase 2 of the following formula are disclosed, along with pharmaceutical compositions comprising them and methods of their use, in particular for treatment of inflammatory and cancerous and ocular diseases.
X is O or NR A ;
A is cycloalkyl, aryl or heterocyclyl;
R A is hydrogen, cyano, nitro, RA 1 , SO 2 RA 1 or SO 2 N(RA 1 ) 2 ;
each R B is independently hydrogen or alkyl.
The other variables are as defined in the claims.