| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel individual compounds of class of mesoionic heterocyclic systems - substituted chlorides of 2-[(1Z)-1-(3,5-diaryl-1,3,4-thiadiazol-2(3H)-ylidene)methyl]-3,5-diaryl-1,3,4-thiadiazol-3-ium of general formula I, where: R = 3,5-diFCH; R= 4-FCH(Ia); R = 4-FCH; R= Ph (Ib); R = 3,5-diFCH; R= Ph (Ic); R = 3,5-diClCH; R= Ph (Id); R = 4-NOCH; R= Ph (Ie); R = Bn; R= Ph (If). Substituted chlorides, presented by formula, are obtained by interaction of substituted N'-arylthiobenzhydrazide with malonyldinitrile in ratio 2:1 in medium of polar organic solvent (demethylformamide) and hydrogen chloride, and reaction mixture is initially saturated by dry hydrogen chloride, and then, without stopping hydrogen chloride supply, heated to 60°C and exposed for an hour with the following product separation. To separate product cooled reaction mixture is poured out on finely-milled ice, mixed and precipitated sediment is filtered out.EFFECT: obtaining novel compounds which can be applied in medicine as antimicrobial medications, with high output.3 cl, 5 tbl, 8 ex |
