发明名称 |
COMPOSITIONS AND METHODS FOR IMPROVING NANOPORE SEQUENCING |
摘要 |
<p>The present disclosure provides methods and reagents for improving nanopore-based analyses of polymers. Specifically, the disclosure provides a method of analyzing a polymer that includes a polymer analyte that contains an end domain that has at least one charged moiety. The disclosure also provides a method of increasing the interaction rate between a polymer analyte and a nanopore, wherein the polymer analyte contains an end domain that has at least one charged moiety. The disclosure also provide compositions for use with the described methods, including adapter compositions that contain charged moieties, such as phosphate or sulfate groups, and that are configured to being linked to an polymer analyte domain.</p> |
申请公布号 |
HK1205532(A1) |
申请公布日期 |
2015.12.18 |
申请号 |
HK20150105898 |
申请日期 |
2015.06.19 |
申请人 |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO |
发明人 |
GUNDLACH, JENS, H.;LASZLO, ANDREW |
分类号 |
C12Q;C12N;G01N;G06F |
主分类号 |
C12Q |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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