PROCEDE D'ATTENUATION D'UNE BACTERIE DU COMPLEXE MYCOBACTERIUM TUBERCULOSIS POUR LA FABRICATION D'UN VACCIN CONTRE LA TUBERCULOSE

摘要

The present invention concerns the use of a strain of a mycobacterium of the Mycobacterium tuberculosis complex in which a mspA gene capable of expressing a porin A of Mycobacterium smegmatis has been inserted, to produce a vaccine for the prevention of infection with a bacterium of the Mycobacterium tuberculosis complex in a host having eukaryote cells, preferably macrophages, the said strain of mycobacteria thus transformed having reduced growth in the said eukaryote cells.