<p>Provided herein are conformationally stabilized ubiquitin proteins and methods for using the same to identify agents that bind to the stabilized ubiquitin protein or that bind to a protein that interacts with or processes the stabilized form of the ubiquitin protein. Also provided herein are methods for screening for conformationally stabilized proteins having increased binding affinity to a binding partner in comparison to the binding affinity of the wildtype form of the protein to the binding partner.</p>
申请公布号
HK1205524(A1)
申请公布日期
2015.12.18
申请号
HK20150106163
申请日期
2015.06.29
申请人
F. HOFFMANN-LA ROCHE AG
发明人
CORN, JACOB, E.;ZHANG, YINGNAN;PHILLIPS, AARON, H.