X-ray Excited Optical Materials and Methods for High Resolution Chemical Imaging

摘要

X-ray/optical imaging materials are described and techniques as may be used for sensitive and high spatial resolution chemical and biophysical imaging in tissue. The technique uses high spatial resolution deeply penetrating X-rays to excite scintillators which convert the energy to a different frequency, e.g., visible light frequencies. The emitted spectrum is then modulated by a chemical indicating element such as an indicator dye held in optical communication with the scintillators in order to detect specific concentrations in the local area. The materials can include a magnetic element in conjunction with the scintillator and chemical indicating element. The materials can incorporate a biologically active agent for delivery.

主权项

1. A sensing system for imaging of a chemical analyte comprising:
a scintillator that emits optical photons upon excitation by an X-ray; and a chemical indicating chemical indicating element that is in optical communication with said scintillator, said chemical indicating element modifying the optical spectrum of said scintillator in a manner that depends upon the local concentration of said analyte.