发明名称 |
METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS |
摘要 |
The present invention relates to a method for the diagnosis or the prognosis of metastasis in prostate cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for the diagnosis or the prognosis of metastasis in prostate cancer, as well as to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which, comprise determining the c-MAF expression level. Finally, the invention relates to the use of a c-MAF inhibitor as therapeutic target for treating the prostate cancer. |
申请公布号 |
US2015362495(A1) |
申请公布日期 |
2015.12.17 |
申请号 |
US201314435128 |
申请日期 |
2013.10.09 |
申请人 |
INBIOMOTION S.L. |
发明人 |
GOMIS Roger;JEAN-MAIRET Joel |
分类号 |
G01N33/574;A61K31/47;A61K31/675;C12Q1/68;C07K16/18 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
1. An in vitro method for the diagnosis of metastasis in a subject with prostate cancer and/or for the prognosis of the tendency to develop metastasis in a subject with prostate cancer, said method comprising:
(i) quantifying the c-MAF gene expression level in a prostate tumor sample of said subject and (ii) comparing the expression level obtained in (i) with the expression level of the c-MAF gene in a control sample, wherein if the expression level of the c-MAF gene in said tumor sample is increased with respect to the expression level of the c-MAF gene in the control sample, then said subject has a positive diagnosis for metastasis or a greater tendency to develop metastasis. |
地址 |
Barcelona ES |