| 发明名称 |
MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE |
| 摘要 |
The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. |
| 申请公布号 |
US2015359872(A1) |
申请公布日期 |
2015.12.17 |
| 申请号 |
US201514839247 |
申请日期 |
2015.08.28 |
| 申请人 |
NOVAVAX, INC. |
发明人 |
PUSHKO Peter;Wu Yingyun;Massage Michael J.;Liu Ye;Smith Gale;Zhou Bin |
| 分类号 |
A61K39/155;A61K9/107;A61K9/00;C07K14/005;C12N7/00 |
主分类号 |
A61K39/155 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A trimeric RSV F protein, wherein the RSV F protein comprises a deletion of up to 10 amino acids corresponding to the fusion domain of residues 137-146 of SEQ ID NO:2, wherein the RSV F protein induces the production of neutralizing antibodies, and wherein the antibodies recognize the RSV F protein in a post-fusion state. |
| 地址 |
Gaithersburg MD US |
