发明名称 |
HUMAN CYTOLYTIC FUSION PROTEINS |
摘要 |
The technology provided herein relates to novel human cytolytic fusion proteins (hCFPs) suitable to induce apoptosis in human cells comprising a target cell-specific binding component and a human effector domain, wherein the binding component comprises an antibody or an antibody fragment with an antigen-binding site for binding to the cellular surface receptor CD64 and the effector domain comprises a variant of wild type human angiogenin (Ang) or a functional fragment thereof; to nucleic acid molecules encoding said recombinant hCFPs, vectors and host cells containing said nucleic acids and methods for preparation and producing these hCFPs. |
申请公布号 |
WO2015189427(A1) |
申请公布日期 |
2015.12.17 |
申请号 |
WO2015EP63282 |
申请日期 |
2015.06.15 |
申请人 |
CURIT BIOTECH HOLDING GMBH |
发明人 |
BARTH, PROF. DR. DR. STEFAN;NACHREINER, DR. THOMAS;CREMER, CHRISTIAN |
分类号 |
C07K14/515;A61K38/18;C07K16/28 |
主分类号 |
C07K14/515 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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