发明名称 |
TARGETING APTAMER FOR ATHEROSCLEROSIS AND PREPARATION METHOD AND APPLICATION THEREOF |
摘要 |
Disclosed are a targeting aptamer for atherosclerosis and a preparation method and application thereof. The targeting aptamer is a targeting aptamer fragment for atherosclerosis obtained through screening of macrophage-derived foam cells together with reverse screening of smooth muscle cells, endothelial cells, and THP-1 cells using a SELEX method; and the use of the targeting aptamer in preparation of an MRI targeting nano-contrast agent for atherosclerosis allows the specific binding of the MRI targeting nano-contrast agent for atherosclerosis only with the macrophage-derived foam cells, and allows high specific binding thereof with vascular tissues with AS lesion, this improving targeting effect of the MRI targeting nano-contrast agent for atherosclerosis and realizing early specific diagnosis of arterial sclerosis. |
申请公布号 |
US2015359910(A1) |
申请公布日期 |
2015.12.17 |
申请号 |
US201314763815 |
申请日期 |
2013.10.14 |
申请人 |
YAN Pengke |
发明人 |
YAN Pengke |
分类号 |
A61K49/18;A61K49/08 |
主分类号 |
A61K49/18 |
代理机构 |
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代理人 |
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主权项 |
1. A MRI targeting nano-contrast agent for atherosclerosis, comprising: a targeting, aptamer for atherosclerosis and a vector which is connected to the targeting aptamer for atherosclerosis, wherein the targeting aptamer for atherosclerosis is a targeting aptamer fragment for atherosclerosis obtained through screening of macrophage-derived foam cells together with reverse screening of smooth muscle cells, endothelial cells, and THP-1 cells using, a SELEX method. |
地址 |
Guangzhou CN |