发明名称 THIO COMPOUNDS
摘要 A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of:;;wherein A, B and D are each oxygen or sulfur, provided that least one of A, B and D is sulfur; and R1-R8 are each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group.
申请公布号 US2015359784(A1) 申请公布日期 2015.12.17
申请号 US201514746512 申请日期 2015.06.22
申请人 The United States of America, as represented by the Secretary, Department of Health and Human Serv 发明人 Greig Nigel H.;Luo Weiming;Tweedie David;Holloway Harold W.;Yu Qian-Sheng;Goetzl Edward J.
分类号 A61K31/454 主分类号 A61K31/454
代理机构 代理人
主权项 1. A method for treating a neurodegenerative disorder in a subject, comprising administering to the subject a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein A, B, D and E are each oxygen or sulfur, and R2-R4 and R6-R8 are each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group, provided that A and B are sulfur, and D and E are oxygen, orA and D are sulfur, and B and E are oxygen, orB and E are sulfur, and A and D are oxygen, orD and E are sulfur, and A and B are oxygen; or
地址 Bethesda MD US