发明名称 |
FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO |
摘要 |
Disclosed are prodrugs of cytotoxic anthracyclines (such as doxorubicin) and other therapeutic agents that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful for targeted delivery of cytotoxic and other agents to FAP- expressing tissues, including cancer (e.g., solid tumors). Also provided are pharmaceutical compounds comprising the prodrugs, as well as methods of using the prodrugs to treat a disorder characterized by FAP upregulation, e.g., cancer, fibrosis, and inflammation. |
申请公布号 |
CA2952051(A1) |
申请公布日期 |
2015.12.17 |
申请号 |
CA20152952051 |
申请日期 |
2015.06.15 |
申请人 |
TRUSTEES OF TUFTS COLLEGE |
发明人 |
BACHOVCHIN, WILLIAM W.;LAI, HUNG-SEN;SANFORD, DAVID G.;POPLAWSKI, SARAH E.;WU, WENGEN |
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