| 发明名称 |
MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER |
| 摘要 |
<p>A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148- clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.</p> |
| 申请公布号 |
WO2015120206(A9) |
申请公布日期 |
2015.12.17 |
| 申请号 |
WO2015US14695 |
申请日期 |
2015.02.05 |
| 申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
SHIH, JEAN, C.;HOFMAN, FLORENCE, M.;CHEN, THOMAS, C. |
| 分类号 |
A61K31/135;A61K31/138;A61K31/352;A61K31/353;A61K31/381;A61K31/404;A61K31/5375;A61P35/00 |
主分类号 |
A61K31/135 |
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