| 主权项 |
1. A pharmaceutical composition comprising a compound of the following formulas:wherein:
R is selected from the group consisting of hydrogen, lower alkyl (C1-C6), lower haloalkyl (C1-C6), lower alkoxy (C1-C6), lower alkenyl (C2-C6), lower alkynyl (C2-C6), lower cycloalkyl (C3-C6) aryl, heteroaryl, heterocyclic, alkylaryl, arylalkyl, hydroxyl, nitro, cyano, cyanoalkyl, azido, azidoalkyl, formyl, hydrazino, halo, OR′, N(R′)2, SR′, COOR′, COR′, OCOR′, NHCOR′, N(COR′)COR′, SCOR′, OCOOR′, and NHCOOR′, wherein each R′ is independently H, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, aryl, heteroaryl, alkylaryl, or arylalkyl, wherein the groups can be substituted with one or more substituents as defined above, R1 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C126 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, aryl, heteroaryl, heterocyclic, alkylaryl, and arylalkyl, R2 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, aryl, heteroaryl, heterocyclic, alkylaryl, arylalkyl, hydroxyl, nitro, cyano, cyanoalkyl, azido, azidoalkyl, formyl, hydrazino, halo, OR′, N(R′)2, SR′, COOR′, COR′, OCOR′, NHCOR′, N(COR′)COR′, SCOR′, OCOOR′, and NHCOOR′, wherein each R′ is independently H, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, aryl, heteroaryl, alkylaryl, or arylalkyl R3 and R4, are, independently, the same or different, and are selected from the group consisting of hydrogen and C1-6 alkyl, R5 is —OR6, —NHR6, —CH2R6, or —CH2CH2R6, R6=—CH2CO2H, —CH2NR3R4, phenyl (“Ph”), or PhR (wherein the R moiety is ortho, meta, or para to the —O, —NH, —CH2, or —CH2CH2 moiety attached to the phenyl substituent in R5), n is 0, 1, or 2, and X is NR′, 0, S, Se, or CR2, and pharmaceutically acceptable salts thereof. |
