| 主权项 |
1. Compounds of formula (I) wherein: X1, X2 independently from each other denote N or CW; V denotes an at least one nitrogen atom comprising moiety selected from the group consisting of:
(i) NR4R5;(ii) CN; R1 independently denotes H, cycloalkyl, aryl, heteroaryl, heterocyclyl or CN, wherein alkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl can optionally be substituted by one or more identical or different substituents T;
or R1 and V together with the carbon atoms to which they are attached to form heterocyclyl or heteroaryl comprising at least one nitrogen atom, which can optionally be substituted by one or more identical or different substituents T; R2, R3 independently from each other denote H, CN, C(O)—N═C—(NYY)2, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, C(O)-alkyl, C(O)OH, C(O)O-alkyl, wherein alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl moieties can optionally be substituted by one or more identical or different substituents T;
or R2 and R3 together with the carbon atoms to which they are attached to form cycloalkyl, heterocyclyl, aryl or heteroaryl, which can optionally be substituted by one or more identical or different substituents T;or, if X2 is CW, X2 and R3 together with the carbon atoms to which they are attached to form cycloalkyl, heterocyclyl, aryl or heteroaryl, which can optionally be substituted by one or more identical or different substituents T; R4, R5 independently from each other denote H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, which can optionally be substituted by one or more identical or different substituents T;
or R4 and R5 together with the nitrogen atom to which they are attached to form heterocyclyl or heteroaryl, which can optionally be substituted by one or more identical or different substituents T; W independently from each other denotes H, CN, NYY, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, C(O)—C(O)O-alkyl, wherein alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl moieties can optionally be substituted by one or more identical or different substituents T; T denotes independently from each other alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halogen, F, Cl, Br, I, OH, CN, NO2, NYY, CF3, OCF3, alkyl-OH, alkyl-NYY, alkyl-CN, alkyl-C(O)-heterocyclyl, O-alkyl, O-cycloalkyl, O-alkyl-cycloalkyl, O-aryl, O-alkyl-aryl, O-heteroaryl, O-alkyl-heteroaryl, O-heterocyclyl, O-alkyl-heterocyclyl, O-alkyl-NYY, C(O)OY, C(O)NY-alkyl-NYY, C(O)NYY, C(O)—C(O)—NYY, C(O)-alkyl-NY-alkyl, C(O)-alkyl-NY-alkyl-O-alkyl, C(O)-alkyl, C(O)-cycloalkyl, C(O)-alkyl-cycloalkyl, C(O)-aryl, C(O)-alkyl-aryl, C(O)-heteroaryl, C(O)-alkyl-heteroaryl, C(O)-heterocyclyl, C(O)-alkyl-heterocyclyl, C(O)NY-alkyl, C(O)NY-cycloalkyl, C(O)NY-alkyl-cycloalkyl, C(O)NY-aryl, C(O)NY-alkyl-aryl, C(O)NY-heteroaryl, C(O)NY-alkyl-heteroaryl, C(O)NY-heterocyclyl, C(O)NY-alkyl-heterocyclyl, S(O)2-alkyl, S(O)2-cycloalkyl, S(O)2-alkyl-cycloalkyl, S(O)2-aryl, S(O)2-alkyl-aryl, S(O)2-heteroaryl, S(O)2-alkyl-heteroaryl, S(O)2-heterocyclyl, S(O)2-alkyl-heterocyclyl, wherein alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl moieties can optionally be substituted by one or more identical or different substituents Z; Y denotes independently from each other H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, wherein alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl can optionally be substituted by one or more identical or different substituents Z; Z denotes independently from each other alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halogen, F, Cl, Br, I, OH, CN, NO2, NH2, NH-alkyl, N(alkyl)2, NH-alkyl-OH, NH-alkyl-O-alkyl, NH-alkyl-aryl, CF3, OCF3, alkyl-OH, alkyl-NH2, alkyl-NH-alkyl, alkyl-N(alkyl)2, alkyl-CN, alkyl-C(O)-heterocyclyl, O-alkyl, O-cycloalkyl, O-alkyl-cycloalkyl, O-aryl, O-alkyl-aryl, O-heteroaryl, O-alkyl-heteroaryl, O-heterocyclyl, O-alkyl-heterocyclyl, O-alkyl-NH2, C(O)OH, C(O)NH-alkyl-NH2, C(O)NH2, C(O)—C(O)—NH2, C(O)-alkyl-NH-alkyl, C(O)-alkyl-NH-alkyl-O-alkyl, C(O)-alkyl, C(O)-cycloalkyl, C(O)-alkyl-cycloalkyl, C(O)-aryl, C(O)-alkyl-aryl, C(O)-heteroaryl, C(O)-alkyl-heteroaryl, C(O)-heterocyclyl, C(O)-alkyl-heterocyclyl, C(O)-heterocyclylalkyl, C(O)NH-alkyl, C(O)NH-cycloalkyl, C(O)NH— alkyl-cycloalkyl, C(O)NH-aryl, C(O)NH-alkyl-aryl, C(O)NH-heteroaryl, C(O)NH-alkyl-heteroaryl, C(O)NH— heterocyclyl, C(O)NH-alkyl-heterocyclyl, C(O)NH-aryl-halogen, C(O)NH-aryl-O-alkyl, C(O)N(alkyl)-aryl, C(O)N(aryl)2, S(O)2-alkyl, S(O)2-cycloalkyl, S(O)2-alkyl-cycloalkyl, S(O)2-aryl, S(O)2-alkyl-aryl, S(O)2-heteroaryl, S(O)2-alkyl-heteroaryl, S(O)2-heterocyclyl, S(O)2-alkyl-heterocyclyl; and the physiologically acceptable salts, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. |
