发明名称 |
HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN PROTEASE-ACTIVATED RECEPTOR-2 |
摘要 |
PROBLEM TO BE SOLVED: To provide high affinity human antibodies to human protease-activated receptor-2.SOLUTION: The present invention provides antibodies that bind to protease-activated receptor-2 (PAR-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human PAR-2. The antibodies of the invention are useful, inter alia, for the treatment of diseases and disorders associated with one or more PAR-2 biological activities, including the treatment of pain conditions, inflammatory conditions and gastrointestinal conditions. The present invention also includes the use of an anti-PAR-2 antibody or antigen binding portion of an antibody of the invention in the manufacture of a medicament for the treatment of a disease or disorder related to or caused by PAR-2 activity in a patient. |
申请公布号 |
JP2015227381(A) |
申请公布日期 |
2015.12.17 |
申请号 |
JP20150177339 |
申请日期 |
2015.09.09 |
申请人 |
REGENERON PHARMACEUTICALS INC |
发明人 |
LYNN MACDONALD;MURPHY ANDREW J;PAPADOPOULOS NICHOLAS J;MARC R MORRA;ROBERT R SALZLER;MICHAEL L LACROIX-FRALISH |
分类号 |
C07K14/705;A61K31/573;A61K39/395;A61K45/00;A61P1/04;A61P1/18;A61P11/06;A61P17/00;A61P17/04;A61P19/04;A61P25/04;A61P29/00;A61P37/08;A61P43/00 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|