INHIBITION OF MACROPHAGE MIGRATION INHIBITORY FACTOR IN MELANOMA AND COLON CANCER

摘要

Compounds and compositions are provided which inhibit MIF. Methods of treatment of melanoma and colon cancers are also provided.

主权项

1. A compound having the following structure: wherein bond α is either present or absent, and when bond α is absent R1 is a monohalo substitution or a dihalo substitution, and when bond α is present R1 is H, a monohalo substitution or a dihalo substitution, wherein R2 is a C1-C10 alkyl, a C2-C10 alkenyl, a C2-C10 alkynyl, an aryl, a heterocyclic, or —C(O)(OH),or a stereoisomer of the compound thereof or a pharmaceutically acceptable salt of the compound.