The present invention relates to 2-amino-4-arylpyrimidine and 2-amino-4-aryltriazine compounds as inhibitors of heat shock protein 90 family of chaperone proteins. The invention also features pharmaceutical compositions and kits that include the compounds and compositions of the invention. The invention further relates to the medical use of these compounds and compositions for the treatment of a disorder in a subject. For example, the disorder is a neurodegenerative disease.
申请公布号
CA2952230(A1)
申请公布日期
2015.12.17
申请号
CA20152952230
申请日期
2015.06.15
申请人
YUMA THERAPEUTICS, INC.;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人
CUNY, GREGORY D.;GLICKSMAN, MARCIE A.;HODGETTS, KEVIN J.;MATHIEU, STEVEN L.;PERRELLA, YUKARI Y.;DARMENCY, VINCENT;LUSIC, HRVOJE