PHENYL-SUBSTITUTED TRIAZINE COMPOUND SERVING AS EGFR INHIBITOR AND APPLICATIONS THEREOF

摘要

The present invention relates to the field of medicinal chemistry and specifically relates to a phenyl-substituted triazine compound providing epidermal growth factor receptor (EGFR) inhibition effects, a pharmaceutical composition comprising the compound, and uses of the compound or pharmaceutical composition serving as a medicament for cancer treatment. The compound provided in the present invention provides great inhibitory activities against mutant EGFR kinases, expresses excellent selectivity, and is expected to become a medicament having specific therapeutic effects against drug-resistant tumors and specifically EGFR mutation-induced drug-resistant tumors.