发明名称 |
CONJUGATES COMPRISING AN ANTI-EGFR1 ANTIBODY |
摘要 |
The present invention relates to a conjugate comprising an anti-EGFR1 antibody or an EGFR binding fragment thereof and at least one dextran derivative, wherein the dextran derivative comprises at least one D-glucopyranosyl unit, wherein at least one carbon selected from carbon 2, 3 or 4 of the at least one D-glucopyranosyl unit is substituted by a substituent of the formula -O-(CH2)n-S-B12H11 2- wherein n is in the range of 3 to 10; and the dextran derivative is bound to the anti-EGFR antibody or an EGFR1 binding fragment thereof via a bond formed by a reaction between at least one aldehyde group formed by oxidative cleavage of a D-glucopyranosyl unit of the dextran derivative and an amino group of the anti-EGFR1 antibody or an EGFR1 binding fragment thereof. |
申请公布号 |
CA2952026(A1) |
申请公布日期 |
2015.12.17 |
申请号 |
CA20152952026 |
申请日期 |
2015.06.12 |
申请人 |
TENBORON OY |
发明人 |
LEPPANEN, ANNE;EKHOLM, FILIP S.;HELIN, JARI;SALO, HANNA;KANERVA, ANNE |
分类号 |
C12N15/13;A61K41/00;A61P35/00;C07K16/28;C12N1/21;C12N15/70 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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