ANTIBODY MOLECULES WHICH BIND TO IL-17A AND IL-17F

摘要

PROBLEM TO BE SOLVED: To provide antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing the antibody molecules.SOLUTION: An antibody molecule is capable of specifically binding to both IL-17A and IL-17F; and preferably also binding to the IL-17A/IL-17F heterodimer, neutralizing the activity of both of them, and inhibiting the biological activity of both IL-17A and IL-17F. The present invention also provides a method of using such antibodies in the treatment of and/or prophylaxis of a disease mediated by either or both of IL-17A and IL-17F such as autoimmune or inflammatory disease or cancer.