| 主权项 |
1. A bioremodelable encasement structure, comprising:
a bioremodelable encasement structure formed from at least one sheet member comprising a first bioremodelable composition, said encasement structure comprising an internal region configured to receive a device therein and an outer surface, said bioremodelable composition comprising ECM from a mammalian tissue source selected from the group consisting of small intestine submucosa (SIS), urinary bladder submucosa (UBS), urinary basement membrane (UBM), liver basement membrane (LBM), stomach submucosa (SS), mesothelial tissue, collagen, subcutaneous extracellular matrix, large intestine extracellular matrix, placental extracellular matrix, omentum extracellular matrix, heart extracellular matrix, and lung extracellular matrix, said encasement structure further comprising an anti-microbial agent selected from the group consisting of neomycin, polymyxin b, bacitracin, gramicidin, gentamicin, oyxtetracycline, ciprofloxacin, ofloxacin, tobramycin, amikacin, vancomycin, cefazolin, ticarcillin and chloramphenicol, said encasement structure being configured to induce modulated healing of tissue when implanted in a subject, said modulated healing including modulation of inflammation of said tissue and induced cell and tissue proliferation, bioremodeling, and regeneration of tissue structures with site-specific structural and functional properties. |
