ANDROGEN RECEPTOR DOWN-REGULATING AGENTS AND USES THEREOF

摘要

The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds are potential agents for the treatment of all forms of prostate cancer and other diseases that depend on functional AR.

主权项

1. A compound of Formula I:or pharmaceutically acceptable salt thereof, wherein:
each of R1 and R2 is independently hydrogen, alkoxy, or CN; R3 is hydrogen or halo; and wherein at least one of R1, R2, R3 is not hydrogen.