发明名称 |
PRETARGETED ACTIVATABLE CELL PENETRATING PEPTIDE WITH INTRACELLULARLY RELEASABLE PRODRUG |
摘要 |
Disclosed herein, the invention pertains to methods and compositions that find use in treatment, diagnosis, prognosis and characterization of disease and disease samples based on the ability of a disease sample to cleave a MTS molecule of the present invention. The MTS molecules of the present invention have a formula as disclosed herein and wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X and Y are linkers; P is a pre-targeting moiety; M is a macromolecular carrier, C is a detectable moiety; and T is a compound for delivery to a target, including for example a therapeutic compound. |
申请公布号 |
US2015359902(A1) |
申请公布日期 |
2015.12.17 |
申请号 |
US201414764132 |
申请日期 |
2014.01.29 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
Savariar Elamprakash N.;Crisp Jessica;Tsien Roger Y. |
分类号 |
A61K47/48;A61K38/06;A61K49/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
1. A molecule comprising the formula:wherein the molecule comprises:
a pre-targeting moiety P; a macromolecular carrier M; a peptide A with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; a first cleavable linker X; a second cleavable linker Y; a compound T; a peptide B with a sequence comprising 5 to 20 consecutive basic amino acids; and n is an integer between 1 and 20. |
地址 |
Oaklnad CA US |