发明名称 |
In vitro production of red blood cells with sortaggable proteins |
摘要 |
Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject. |
申请公布号 |
AU2014262474(A1) |
申请公布日期 |
2015.12.17 |
申请号 |
AU20140262474 |
申请日期 |
2014.05.09 |
申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
LODISH, HARVEY;PLOEGH, HIDDE L.;LEE, HSIANG-YING;SHI, JIAHAI;KUNDRAT, LENKA;PISHESHA, NOVALIA |
分类号 |
C07K19/00;C12N5/078;C12N9/00;C12N9/10;C12N15/85 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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