发明名称 |
Mediators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto |
摘要 |
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
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申请公布号 |
US2009012082(A1) |
申请公布日期 |
2009.01.08 |
申请号 |
US20050718470 |
申请日期 |
2005.11.03 |
申请人 |
CURIS, INC. |
发明人 |
GUICHERIT OLIVIN M.;BOYD EDWARD ANDREW;BOYD JUDITH;BRUNTON SHIRLEY ANN;PRICE STEPHEN;STIBBARD JOHN HARRY ALEXANDER;MACKINNON COLIN H. |
分类号 |
A61K31/5377;A61K31/4439;A61K31/444;A61K31/4545;A61P35/00;C07D211/68;C07D401/02;C07D401/14;C07D413/02;C07D413/14;C07D417/02;G01N33/53 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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