发明名称 |
NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION |
摘要 |
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof are provided: Formula I wherein: each (L)k-Ar1 is a substituted or unsubstituted, mono or bicyclic aryl or heteroaryl; W is a bond, alkyl, or alkenyl; X is a bond, NR1 or O and each R1 and R2 is independently H, alkyl, alkenyl or aralkyl or R1 and R2 taken together form a 5-8 membered ring; R3 R6 are selected from certain specific substituents or a carbonyl; Y is a bond, O, S, SO, SO2, CH2, NH, N(alkyl), or NHC(=0); and Z is OH, NR6R7, NR8SO2(alkyl), NR8C(O)NR6R7, NR8C(O)O(alkyl), NR8- dihydrothiazole, or NR8-dihydroimidazole or wherein Z can fuse with Ar2 to form selected heterocycles. |
申请公布号 |
WO2009006437(A1) |
申请公布日期 |
2009.01.08 |
申请号 |
WO2008US68843 |
申请日期 |
2008.06.30 |
申请人 |
EMORY UNIVERSITY;NEUROP, INC.;LIOTTA, DENNIS, C.;SNYDER, JAMES, P.;TRAYNELIS, STEPHEN, F.;WILSON, LAWRENCE;MOSLEY, CARA;DINGLEDINE, RAYMOND, J.;MYERS, SCOTT;TAHIROVIC, YESIM, ALTAS |
发明人 |
LIOTTA, DENNIS, C.;SNYDER, JAMES, P.;TRAYNELIS, STEPHEN, F.;WILSON, LAWRENCE;MOSLEY, CARA;DINGLEDINE, RAYMOND, J.;MYERS, SCOTT;TAHIROVIC, YESIM, ALTAS |
分类号 |
A61K31/497;A61K31/4965 |
主分类号 |
A61K31/497 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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