| 摘要 |
The present invention relates to the regulation of angiogenesis and tumorigenesis. The invention further relates to methods for identifying and using agents, such as small organic molecules, antibodies, peptides and nucleic acids (e.g., antisense molecules, RNAi molecules and ribozymes), that modulate angiogenesis and tumorigenesis via modulation of IGF-II and, in turn, EphB4, as well as to the use of expression profiles and compositions in the diagnosis and therapy of angiogenesis and cancer. |
