发明名称 |
INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME |
摘要 |
The invention relates to inhibitors of polysialic (PSA) de-N-acetylase, methods of their production and use. The methods involve use of a PSA de-N-acetylase inhibitor for modifying the growth of cells, such as inhibiting the growth of cancer cells. The compositions include an inhibitor of a PSA de-N-acetylase, such as N-substituted derivatives of the amino sugars hexosamine and neuraminic acid, as well as conjugates and aggregates. Also provided are pharmaceutical compositions that include a PSA de-N-acetylase inhibitor of the invention. Kits containing one or more inhibitor compositions of the invention, as well as methods of preparing the compositions also are provided. |
申请公布号 |
WO2009006591(A1) |
申请公布日期 |
2009.01.08 |
申请号 |
WO2008US69194 |
申请日期 |
2008.07.03 |
申请人 |
CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND;MOE, GREGORY, R.;HAGEN, BRENT, T. |
发明人 |
MOE, GREGORY, R.;HAGEN, BRENT, T. |
分类号 |
A01N37/00;A01N43/04;A61K31/70 |
主分类号 |
A01N37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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