| 摘要 |
The invention provides formulations, dosage forms, and treatments comprising cyclohexane polyalcohol compounds that provide beneficial pharmacokinetic profiles in the treatment of a disorder and/or disease including a disorder in protein folding and/or aggregation, and/or amyloid formation, deposition, accumulation, or persistence. In aspects of the invention, a dosage form is provided comprising an amount of a cyclohexane polyalcohol compound suitable for administration to a subject to provide a therapeutically effective concentration of the compound in plasma, brain and/or cerebral spinal fluid and a pharmaceutically acceptable carrier, diluent or excipient. The formulation can be administered in a dose of 500, 1000, 2000, 3500, 5000 or 7000 mg of cyclohexane polyalcohol compound to achieve a mean plasma concentration profile having a mean AUC0-INF in [mu].h/mL of, respectively, 43+-20%, 130+-20%, 215+-20%, 467+-20%, 507+-20% or 885+-20%, and having a mean Cmax in [mu]mL of, respectively, 5.8+-20%, 17+-20%, 33+-20%, 75+-20%, 110+-20% or 155+-20%. |
