发明名称 |
METHODS AND USES RELATED TO RHBDL4 |
摘要 |
<p>The invention relates to a method of identifying a modulator of RHBDL4, said method comprising (i) providing a first and second sample of cells; (ii) contacting said first sample of cells with a candidate modulator of RHBDL4; (iii) measuring epidermal growth factor receptor (EGFR) transactivation in said first and second samples of cells, wherein a difference between the transactivation measured in said first and second samples of cells identifies said candidate modulator of RHBDL4 as a modulator of RHBDL4. The invention also relates to RHBDL4 protease assays and to uses of RHBDL4 protease and methods of cleavage of RHBDL4 substrates.</p> |
申请公布号 |
EP2155895(A2) |
申请公布日期 |
2010.02.24 |
申请号 |
EP20080736959 |
申请日期 |
2008.04.11 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
LEMBERG, MARIUS, KASPER;FREEMAN, MATTHEW |
分类号 |
C12Q1/37;A61K48/00 |
主分类号 |
C12Q1/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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