MODIFIED ERYTHROPOIETIN POLYPEPTIDES AND USES THEREOF FOR TREATMENT

摘要

PURPOSE: A modified erythropoietin(EPO) polypeptide and a polypeptide for treating are provided to ensure protein stability and improve therapeutic characteristic. CONSTITUTION: A pharmaceutical composition contains a modified polypeptide inside a pharmaceutically acceptable vehicle or an active fragment of the polypeptide. A non-modified polypeptide comprises at least one saccharification site and the saccharification is needed for therapeutic activity of the non-modified polypeptide. At least one modified polypeptide is substituted, inserted and/or deleted in the modified polypeptide comparing to the non-modified polypeptide. The modified polypeptide has enhanced resistance to protein lysis and therapeutic activity without saccharification. The modified polypeptide is cytokine, erythropoietin.