发明名称 |
COMPOUNDS FOR THE TREATMENT OF WEIGHT LOSS |
摘要 |
A method of treating weight loss due to underlying disease in a patient, the method comprising administering to the patient an effective amount of an agent which reduces sympathetic nervous system activity. A method of treating weight loss due to underlying disease in a patient, the method comprising administering to the patient an effective amount of any one or more of the following: a compound which inhibits the effect of aldosterone such as an aldosterone antagonist; a chymase inhibitor; a cathepsin B inhibitor; a &bgr; receptor blocker; an imidazoline receptor antagonist; a centrally acting α receptor antagonist; a peripherally acting α receptor antagonist; a ganglion blocking agent; a drug that has an effect on cardiovascular reflexes and thereby reduces SNS activity such as an opiate; scopolamine; an endothelin receptor antagonist; and a xanthine oxidize inhibitor. The methods are particularly useful in treating cardiac cachexia. |
申请公布号 |
EP1121111(B1) |
申请公布日期 |
2010.02.10 |
申请号 |
EP19990947762 |
申请日期 |
1999.10.15 |
申请人 |
IMPERIAL INNOVATIONS LIMITED |
发明人 |
ANKER, STEFAN, D.;COATS, ANDREW, J. S. |
分类号 |
A61K31/165;A61K45/00;A61K31/00;A61K31/14;A61K31/167;A61K31/198;A61K31/403;A61K31/404;A61K31/4164;A61K31/4178;A61K31/433;A61K31/439;A61K31/485;A61K31/517;A61K31/56;A61K31/585;A61K31/663;A61K38/00;A61K38/55;A61K41/00;A61K45/06;A61P1/16;A61P3/00;A61P3/10;A61P9/04;A61P9/12;A61P11/00;A61P13/12;A61P31/00;A61P31/18;A61P35/00 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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