发明名称 |
DYES HAVING RATIOMETRIC FLUORESCENCE RESPONSE FOR DETECTING METABOLITES |
摘要 |
The presently disclosed subject matter provides thiol-reactive, environmentally sensitive fluorescent dyes, or fluorophores, which have an emission wavelength in the visible spectral region. When conjugated with a binding protein, the fluorophores exhibit a ratiometric response to one or more ligands or target analytes. The presently disclosed fluorophore-binding protein conjugates can be used to detect the presence of or amount of physiologically-important metabolites, such as glucose, fatty acids, and lactate, in biological samples. |
申请公布号 |
EP2150586(A2) |
申请公布日期 |
2010.02.10 |
申请号 |
EP20080756041 |
申请日期 |
2008.05.21 |
申请人 |
BECTON, DICKINSON AND COMPANY |
发明人 |
THOMAS, JOSEPH;CASH, MICHAEL, T. |
分类号 |
C09B57/02;G01N33/533;G01N33/58 |
主分类号 |
C09B57/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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