ABETA (X-38..43) OLIGOMERS, AND PROCESSES, COMPOSITIONS, AND USES THEREOF

摘要

The present invention relates to an Aß(X - 38.. 43) oligomer having a high molecular weight, or a derivative thereof, a process for preparing the oligomer or derivative, compositions comprising the oligomer or derivative, and uses of the oligomer or derivative such as its use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the Aß(X - 38.. 43) oligomer or derivative. The subject invention also describes agents that are capable of binding to the Aß(X - 38.. 43) oligomer or derivative, e.g. antibodies, compositions comprising the agents, and uses of the agents such as their use for treating or preventing an amyloidosis (e.g. by passive immunization) and for diagnosing an amyloidosis.