发明名称 Construct and method for the internalization of cargo molecules into a cell
摘要 <p>The present invention relates to the delivery of molecules into cells. Especially, it relates to a carrier complex comprising (i) a molecule comprising a receptor peptide and a peptide which is capable of penetrating a host cell; and (ii) a second molecule comprising a ligand peptide and a cargo molecule of interest. In a preferred embodiment, the carrier complex comprises (i) a fusion protein between the TAT-peptide of HIV I and the streptactin, a streptavidin mutant; and (ii) a conjugate or a fusion protein between the strep-tag II, a streptavidin, binding peptide, and the cargo molecule to be delivered.</p>
申请公布号 EP2147683(A1) 申请公布日期 2010.01.27
申请号 EP20080161192 申请日期 2008.07.25
申请人 DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM 发明人
分类号 A61P3/00;A61K47/48;A61P9/00;A61P25/00;A61P29/00;A61P31/00;A61P35/00;A61P37/00 主分类号 A61P3/00
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