发明名称 |
METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA |
摘要 |
<p>A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 514 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 514 (step B). According to the method of the present invention, the level of an onset risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention on the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.</p> |
申请公布号 |
EP2147975(A1) |
申请公布日期 |
2010.01.27 |
申请号 |
EP20080751865 |
申请日期 |
2008.04.17 |
申请人 |
SANTEN PHARMACEUTICAL CO., LTD;KINOSHITA, SHIGERU;TASHIRO, KEI |
发明人 |
KINOSHITA, SHIGERU;TASHIRO, KEI;NAKANO, MASAKAZU;YAGI, TOMOHITO;MORI, KAZUHIKO;IKEDA, YOKO;TANIGUCHI, TAKAZUMI;KAGEYAMA, MASAAKI |
分类号 |
C12N15/09;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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