发明名称 |
THERAPEUTIC AGENT COMPRISING ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO HUMAN HMGB-1 AS ACTIVE INGREDIENT |
摘要 |
<p>Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect.</p> |
申请公布号 |
EP2123297(A1) |
申请公布日期 |
2009.11.25 |
申请号 |
EP20080711330 |
申请日期 |
2008.02.15 |
申请人 |
KUMAMOTO UNIVERSITY;KAGOSHIMA UNIVERSITY;SHINO-TEST CORPORATION |
发明人 |
ANDO, YUKIO;MARUYAMA, IKURO;YAMADA, SHINGO |
分类号 |
A61K39/395;A61P3/00;A61P29/00;A61P31/04;A61P43/00;C07K16/24 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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