摘要 |
<p>A novel method for the production of transgenic proteins of interest suitable for oral administration is disclosed. The method involves the preparation of a protein of interest suitable for oral administration within a non-food crop plant comprising, transforming the non-food crop plant with a suitable vector containing a gene of interest and appropriate regulatory regions to ensure expression of the gene of interest within the non-food crop plant, such that the non-food crop plant is characterized as being non-toxic, non-addictive, palatable, and requiring minimal or no processing prior to oral administration. An example of a non-food crop plant is low lakaloid tobacco. Proteins of interest may include pharmaceutically active proteins such as growth regulators, insulin, interferons, interleukins, growth hormone, erythropoietin, G-CSF, GM-CSF, hPG-CSF, M-CSF, Factor VIII, Factor IX, tPA, antibodies, antigens and combinations and/or derivatives thereof.</p> |
申请人 |
HER MAJESTY THE QUEEN IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF AGRICULTURE AND AGRI-FOOD;QUEEN'S UNIVERSITY;THE JOHN P. ROBARTS RESEARCH INSTITUTE;LONDON HEALTH SCIENCES CENTER |
发明人 |
BRANDLE, JIM;DAVIES, PETER, L.;KENWARD, KIMBERLEY, D.;MENASSA, RIMA;JEVNIKAR, TONY;DELOVITCH, TERRY |