发明名称 |
Heterocyclic antiviral compounds |
摘要 |
Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R<SUP>1</SUP>-R<SUP>3 </SUP>R<SUP>6c </SUP>and X<SUP>1 </SUP>are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I. |
申请公布号 |
ZA200806845(B) |
申请公布日期 |
2009.11.25 |
申请号 |
ZA20080006845 |
申请日期 |
2008.08.07 |
申请人 |
F. HOFFMANN LA-ROCHE AG |
发明人 |
LEMOINE, REMY;MELVILLE, CHRIS RICHARD;PADILLA, FERNANDO;ROTSTEIN, DAVID MARK;WANNER, JUTTA |
分类号 |
A61K;A61P;C07D |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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