发明名称 |
Solid pharmaceutical dosage form |
摘要 |
A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50 °C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10. |
申请公布号 |
ZA200601718(B) |
申请公布日期 |
2009.11.25 |
申请号 |
ZA20060001718 |
申请日期 |
2006.02.27 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
ROSENBERG, JOEERG;LIEPOLD, BERND;BREITENBACH, JOERG;GHOSH, SOUMOJEET;REINHOLD, ULRICH;BERNDL, GUNTHER;ALANI, LAMAN |
分类号 |
A61K;A61K9/14;A61K9/20;A61K9/28;A61K31/425 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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