发明名称 |
MICRONEEDLE DEVICES AND METHODS OF THEIR MANUFACTURE |
摘要 |
Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps. |
申请公布号 |
EP1086214(B1) |
申请公布日期 |
2009.11.25 |
申请号 |
EP19990928580 |
申请日期 |
1999.06.10 |
申请人 |
GEORGIA TECH RESEARCH CORPORATION |
发明人 |
PRAUSNITZ, MARK, R.;ALLEN, MARK, G.;MCALLISTER, DEVIN, V.;HENRY, SEBASTIEN;CROS, FLORENT, PAUL, MARCEL |
分类号 |
C12N15/00;C12N15/09;A61B5/00;A61B5/15;A61B17/20;A61K9/70;A61M35/00;A61M37/00;A61N1/30;B81C1/00 |
主分类号 |
C12N15/00 |
代理机构 |
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地址 |
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