NEW ANTICANCER CONJUGATES

摘要

New conjugates are described, containing camptothecin connected to hyaluronic acid via a linker, where the linker is bound to the hyaluronic acid by means of an ester bond. The ester bond involves on one side, a hydroxyl group of hyaluronic acid and, on the other side, a carboxyl group present on the linker; the linker is covalently bonded to camptothecin. Pharmaceutical compositions thereof, their use in the treatment of pathologies responsive to camptothecin, and a process to prepare said conjugates are also described.