发明名称 |
SMALL MOLECULES FOR NEURONAL DIFFERENTIATION OF EMBRYONIC STEM CELLS |
摘要 |
<p>A method of preparing neural precursor cells by exposing pluripotent stem cells or neural stem cells to a differentiation agent. The agent is a pyridine analog, which in preferred embodiments is a phenylethynyl-substituted or phenylazo- substituted pyridine. In other embodiments, a method of enhancing neural precursor cell survival is provided in which the survival is enhanced by exposure to the pyridine analog. In further embodiments, a method of preparing neuronal cells is provided in which pluripotent or neural stem cells exposed to the pyridine analog are then incubated without the pyridine analog, resulting in differentiation into neurons, astrocytes and oligodendrocytes. These methods may be used in toxicological screens, e.g., to evaluate the neurotoxicity of a test compound.</p> |
申请公布号 |
WO2009076529(A1) |
申请公布日期 |
2009.06.18 |
申请号 |
WO2008US86430 |
申请日期 |
2008.12.11 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION;SUTER, DAVID, M.;PREYNAT-SEAUVE, OLIVIER;KRAUSE, KARL-HEINZ |
发明人 |
SUTER, DAVID, M.;PREYNAT-SEAUVE, OLIVIER;KRAUSE, KARL-HEINZ |
分类号 |
C12N5/071;C12N5/0793;C12N5/0797 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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