ANTIVIRAL ACTIVITY OF CYCLOPENTENE NITRO-ESTER AND DERIVATIVES
摘要
<p>Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99% ee) was influenced by desymmetrization catalyzed by Pseudomonas cepacia lipase and the stereoselective nature of the palladium catalyzed transformations</p>
申请公布号
WO2009076397(A2)
申请公布日期
2009.06.18
申请号
WO2008US86155
申请日期
2008.12.10
申请人
UNIVERSITY OF SOUTH FLORIDA;BISHT, KIRPAL S.;VAN OLPHEN, ALBERTO;KHAN, PASHA M.;BUCHER, CYNTHIA