AN INDUSTRIALLY FEASIBLE PROCESS FOR THE MANUFACTURE OF BISQUINOLINE DERIVATIVES BY USING SUBSTANTIALLY PURE N-MONOSUBSTITUTED PIPERAZINES

摘要

A process for the preparation of substantially pure 7-chloro-4-(?i?erazin-1-yl) quinoline of formula II free from dimer impurity of formula III and process for the preparation of substantially pure piperaquine and its acid salt by using pure 7- chloro-4-(piperazin-1-yl) quinoline.